Pei-Yu Irene Liao PhD: Chemical and Biomolecular Engineering MS: National Taiwan University, Department of Chemical Engineering BS: National Taiwan University, Department of Chemical Engineering |
Method development to study the mechanism of +1 and -1 programmed ribosomal frameshifting Programmed ribosomal frameshifting (PRF) is a process in which ribosomes change the reading frame during translation of proteins. Some important viruses, such as human immunodeficiency virus type 1 (HIV-1) and the coronavirus for severe acute respiratory syndrome (SARS-CoV) use -1 PRF to produce specific proteins for their replication. My research is to use computational framework to understand the mechanism of +1 PRF and -1 PRF and develop experimental systems to verify model predictions. |
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Jeffrey Charles Swanberg Jr. PhD: Chemical Engineering BS: Chemical and Biomolecular Engineering, The Johns Hopkins University. |
Metabolic Engineering My research centers on improved protein production in Chinese hamster ovary (CHO) cells. Actin inhibiting drugs are used to induce cytoskeletal changes in CHO cells to improve protein production. Next generation sequencing technologies are used to study CHO cells at the genomic and transcriptomic levels. |
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Anup Agarwal PhD: Chemical Engineering BTech: Biotechnology |
Improved protein secretion in E.coli via the optimization of synonymous codons changes. E.coli is a common host for recombinant protein production for biotechnology applications. Secretion of recombinant proteins to the extracellular and periplasmic space has the potential to reduce protein aggregation and to simplify downstream processing. A directed mutagenesis approach (specifically changing abundant codons to synonymous rare codons) can considerably increase the secretion of recombinant proteins to the extracellular and periplasmic space. |
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Stephanie Hammond PhD: Chemistry and Chemical Biology, Cornell University, 2008 MS: Chemistry and Chemical Biology, Cornell University, 2006 BS: Chemistry,Northern Arizona University, 2003 |
CHO cell productivity Previous studies have shown that altering the actin cytoskeleton can enhance protein secretion in CHO cells. The role of actin cytoskeletal regulatory proteins in this process is being studied at both the protein and genomic levels. |
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Yong Seok Choi PhD: Chemistry MS: Pharmacy Bachelor of Pharmacy:
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Development of a new early diagnostic method for Alzheimer’s disease using mass spectrometry. We are developing a new method to monitor Alzheimer’s disease (AD) biomarkers in non-depleted human cerebrospinal fluid using a LC-MS technique with multiple reaction monitoring, a significantly sensitive and specific mass scan method, for the early diagnosis of AD. Additionally, we are working on the development of analytical methods to identify or/and quantify molecules in various samples such as proteins extracted from E. coli, metabolites from marine microbes, and plant phytotoxins using mass spectrometry. |
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Jeffrey A. Foltz Research Associate: MS: Animal Science/Virology, University of Delaware BS: Animal Science, University of Delaware
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Leila Choe Associate Scientist BS: Biology, University of California, Riverside
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G S PhD: Biomedical Engineering MS: Biomedical Engineering Cornell University, Ithaca, NY BA: Genetics & Development Cornell University, Ithaca, NY |
In Vitro models of the Blood-Brain Barrier I am working on developing a new nanotechnology in vitro model of the blood-brain barrier. I nanofabricate 3um thick, porous membranes with electron beam lithography and use them as an interface for the primary culture of mouse brain microvascular endothelial cells and astrocytes. Further, I am using this model to understand the molecular basis of IVIg therapy in Alzheimer's disease.
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