Overview

Our academic home is the Department of Chemical Engineering and our research laboratories are at the Delaware Biotechnology Institute at the University of Delaware. Our research infrastructure includes modern technologies and techniques for molecular biology, high throughput gene sequencing and gene expression monitoring, proteomics, and cell biology. We work closely with our colleauges from Plant and Soil Science, Biology, Chemistry and Biochemistry, and Materials Science and Engineering. Moreover, we have ongoing collaborations with a number of corporate partners and clinicians.

Research

The research laboratory is focused on the development of next generation tools for protein  expression profiling and the use of existing tools applied to specific problems in biomolecular engineering and medicine. Our current areas of focus include:

1. The use of proteomics in support of a passive immunization clinical trial for the treatment of Alzheimer's disease
2. The study of enhanced heterologous protein secretion in bacterial and mammalian cells including a detailed understanding of protein translation
3. The development of nanoscale materials and technologies for protein separation.

Group

Our research team is an enthusiastic group of undergraduate and graduate students, research associates, and professional staff. We meet regularly as a group, disseminate our findings in a number of regular meetings (American Institute of Chemical Engeering, American Chemical Society BIOT Division, American Society for Mass Spectrometry, International Conference on Alzheimer's Disease, Biochemical Engineering, Cell Culture Engineering, and others.)

 

Recent News

Prateek Gupta gets his PhD and joins Genentech (Roche).

Upcoming Events

ASMS meeting coming to Philadelphia in May 2009.

Latest publications

Liao PY, Gupta P, Petrov A, Dinman J, Lee KH (2008). A new kinetic model
reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal
frameshifting. Nucleic Acids Research. 36: 2619-2629.

D'Ascenzo M, Choe LH, Lee KH (2008). iTRAQPak: an R Based Analysis and
Visualization Package for 8-plex Isobaric Protein Expression Data.
Briefings in Functional Genomics and Proteomics 7: 127-135.

Gupta P, Lee KH (2008). Silent Mutations Result in HlyA Hypersecretion by reducing Intracellular HlyA Protein Aggregates. Biotechnology and Bioengineering 101: 967- 974.